世界*实验材料供应商 BioAustralis正式上海金畔为其中国代理, BioAustralis在一直是行业的*,一直为广大科研客户提供zui为的产品和服务,上海金畔一直秉承为中国科研客户带来的产品,的服务, BioAustralis就是为了给广大科研客户带来更加完善的产品和服务,您的满意将是我们zui大的收获
BioAustralis中国代理, BioAustralis上海代理, BioAustralis北京代理,BioAustralis广东代理,BioAustralis江苏代理BioAustralis湖北代理,BioAustralis天津,BioAustralis黑龙江代理,BioAustralis内蒙古代理,BioAustralis吉林代理,BioAustralis福建代理, BioAustralis江苏代理, BioAustralis浙江代理,BioAustralis四川代理,
澳大利亚BioAustralis提供高纯度的微生物实验室代谢产物的研究工具。BioAustralis专注于和放线菌的分离稀有的代谢产物发酵,细菌和真菌。BioAustralis所有的代谢产物是在其实验室生产以保证可靠的质量,供应和服务。BioAustralis的产品目录,涵盖范围广泛的化学和生物活性。BioAustralis致力于提供了zui的生化抑制剂。
我们的产品目录涵盖广泛的化学和生物活性。我们专注于提供zui近描述的生物化学途径的抑制剂。我们的代谢产物中有超过60%是新兴市场; 它们包括许多*和重要的分子生物探针的类似物。
Mitomycin C
货号: BIA-M1183
规格: 5 mg, 25 mg
Synonyms : Mitomycin, Mitomycin S, Mitiromycin E, Ametycine, Mitocin C, Mutamycin, NSC 26980
Specifications
CAS |
50-07-7 |
Molecular Formula |
C15H18N4O5 |
Molecular Weight |
334.3 |
Source |
Streptomyces sp. |
Appearance |
Blue solid |
Purity |
>98% by HPLC |
Long Term Storage |
-20°C |
Solubility |
Soluble in ethanol, methanol, DMF or DMSO. Moderate water solubility. |
Application Notes
Mitomycin C is the most studied of a family of highly distinctive blue/purple metabolites produced by several Streptomyces species. Mitomycin C exhibits potent antibacterial and antitumor activity and inhibits DNA synthesis by intercalation, blocking nuclear division with the induction of apoptosis in cancer cells.
References
- Mitomycin, a new antibiotic from Streptomyces. I. Hata T. et al., J. Antibiot. 1956, 9, 141.
- DNA sequence specificity of mitomycin cross-linking. Teng S.P. et al., Biochemistry 1969, 28, 3901.
- Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95- independent manner in human gastric adenocarcinoma cells. Park I.C. et al., Cancer Lett. 2000, 158, 125.
- Activation of the S phase DNA damage checkpoint by mitomycin C. Mladenov E. et al., J. Cell. Physiol. 2007, 211, 468.