产品编号

产品名称

中文名称

包装

备注

309-34133

Biostir^® AD

Biostir^® 特应性皮炎诱导剂AD

5 g

软膏包括来自粉尘螨的螨过敏原，-30℃

303-34131

Biostir^® AD

Biostir^® 特应性皮炎诱导剂AD

15 g

项目

方法

动物

特应性皮炎模型服务和药理学测试

 1. 在D粉尘螨具有高含量螨变应原的NC / Nga小鼠中通过Biostir^® AD

     诱导特应性皮炎样损伤。

    
 2. 经皮致敏/免疫小鼠。
    
 3. 高概率获得特应性皮炎模型。
    
 4. 评估测试物质对疾病模型的效力。
    
 5. 评价项目：症状评分，IgE，组织病理学，搔抓行为等。

小鼠
（NC/Nga）

动物

雌性NC / Nga小鼠

特应性皮炎样皮肤损伤的临床方面

在皮肤上观察到搔抓行为，红斑，丘疹，鳞屑，疮痂和苔藓病变

组织学评价

损伤皮肤表现在真皮和表皮显著增厚，角化过度和角化不全。
在损伤小鼠中观察到包括肥大细胞和嗜酸性粒细胞在内的皮肤炎症细胞数量的增加。
损伤小鼠中总数和脱颗粒的肥大细胞的数量多于正常小鼠。

血清总IgE

显著升高

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 2.

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11.

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13.

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14.

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16.

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17.

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23.

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26.

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27.

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29.

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30.

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31.

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32.

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33.

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34.

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44.

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73.

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